Objective:The objective of this study is to compare 5-year follow-up results of One Anastomosis Gastric Bypass / Mini Gastric Bypass (MGB-OAGB) and Laparoscopic Sleeve Gastrectomy (LSG) for the glycemic control and the weight loss achieved.Methods:We compared the change in HbA1c and the body weight across the prospective randomized study in 78 T2DM patients, BMI >35kg/m2 and < 60 kg/m2, who underwent LSG (n=37) and MGB-OAGB (n=41) during 2012 to 2015 and followed for five year. Student t-test and ANOVA were used for statistical analysisResults: The follow-up rate at 5 year after surgery was 72%. The diabetes remission at first, second, third, fourth and fifth year was 83.6 %, 87.7%, 89.1%, 88.1%, 85% in the MGB-OAGB patients and 76.58 %, 85.2%, 81.8%, 70.7%, 56.7%, in the LSG patients, respectively, with significant difference at fourth (p=0.05) and fifth year (p=0.006). The mean HbA1c decrease from baseline to fifth year follow up in MGB-OAGB -3.4 % (SD ±1.3, 95% CI – 3.8 to -3) was significantly higher than in LSG patients was -3.42.6 % (SD ±1.4, 95%CI – 3 to -2.1) (p=0.0086). The mean HbA1c at first, second, third, fourth and fifth year in the MGB-OAGB patients (6.4±0.28, 6.2±0.23, 6.1±0.26, 6.2±0.49, 6.3±0.62) (p=0.0395) and LSG patients was (6.4±0.39, 6.4±0.32, 6.3±0.3, 6.5±0.75, 6.7±1) (p=0.035). The percentage of the excess weight loss at first, second, third, fourth and fifth year was 66.19 %, 64.77 %, 66.48%, 66.6%, 65% in the MGB-OAGB patients and 63.97 %, 62.79%, 61.15%, 58.17%, 55.94%, in the LSG patients, respectively, with significant difference at fourth (p=0.0128) and fifth year (p=0.0099)Discussion/Conclusion:
In our study, we observed that the durability of the reversal of the diabetes, HbA1c reductions and the percentage of excess weight loss, which was statistically significant, in both the patient groups, MGB-OAGB and LSG. The difference between the groups was statistically significant from fourth year follow up onwards with greater metabolic benefits observed in the MGB-OAGB group. The better performance of MGB-OAGB for T2DM remission and sustained glycemic control compared to LSG is possibly due to its restriction, better incretin effect and fat malabsorption. The strength of our study is the comparative distinction for the long term glycemic control for the two different bariatric procedures
We found that DHEAS and ACTH provide additional value in diagnosing MACS. Future studies are needed to evaluate diagnostic accuracy of DHEAS prospectively.