MENA 2024 Recordings-Non-skeletal IDS1C2

Video Transcription

Video Summary

The talk explores potential effects of bisphosphonates beyond bone health, specifically focusing on cardiovascular effects, cancer, mortality, and senescence-related impacts. Regarding cardiovascular health, the speaker examined whether bisphosphonates like alendronate and zoledronate influence conditions such as atrial fibrillation or offer cardioprotective benefits. Findings indicated minimal risk increases for atrial fibrillation, with some trials suggesting zoledronate may offer a mortality benefit, particularly post-fracture, though this was not consistent across all studies. Additionally, zoledronate might possess senolytic properties, potentially reducing senescent cells that contribute to chronic age-related diseases. Preliminary outcomes in mice suggest that zoledronate can improve senescent markers and functional performance indicators, such as grip strength. While there are intriguing insights into the broader impacts of bisphosphonates, the data is not yet conclusive or fully understood, particularly regarding mechanisms and implications for clinical practice.

Asset Subtitle

Dr. Jad Sfeir

Keywords

bisphosphonates

cardiovascular effects

zoledronate

senescence

atrial fibrillation

senolytic properties