Guidelines Development Workshop-Session 3: Review example studies and terminology and rate the quality of the evidence

Video Transcription

Video Summary

In this video, Jonathan Treadwell and Stacey Yule discuss the process of applying the GRADE framework to a specific clinical topic. The video begins with Jonathan giving a brief overview of the topics they will cover: applying GRADE to a clinical topic and crafting recommendations. Jonathan then spends some time defining the terms "relative risk" and "odds ratio" for the audience.<br /><br />After the definitions, Jonathan goes on to present a clinical example of applying GRADE. The example focuses on the impact of dietary nutrient composition on weight loss and cardiovascular disease in obese patients with metabolic syndrome. He mentions two studies, one by McLaughlin in 2006 and one by Muzio in 2007, that will be used to make recommendations. Jonathan walks through the various steps of GRADE, such as assessing study limitations, indirectness, inconsistency, imprecision, and publication bias, for both outcomes.<br /><br />Based on the assessments, the final grades for body weight and cardiovascular disease are determined to be low and very low, respectively. Jonathan highlights the importance of transparency in the GRADE process and the need for subjective judgments in the assessments. He also mentions that upgrades are not applied to randomized trials.<br /><br />The video concludes with Jonathan answering some questions from the audience, including the significance of meta-analyses in the GRADE framework and whether a meta-analysis outweighs individual studies in terms of evidence. Jonathan explains that meta-analyses are just a way to gather the data in one place, and the biases of the individual studies still exist. He emphasizes the importance of examining each study separately and tailoring the assessment to the specific key question. The video then transitions to Stacey, who will discuss the rating of strength of recommendations in the GRADE framework.

Keywords

GRADE framework

clinical topic

applying GRADE

dietary nutrient composition

weight loss

cardiovascular disease