Guidelines Development Workshop-Session 2: Overview of GRADE

Video Transcription

Video Summary

The video provides an overview of the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system, which is a framework used in evidence-based medicine. The GRADE system was developed by a working group of around 100 people in 2004 and has been widely adopted by various societies. It aims to enhance consistency and transparency in making recommendations by assessing the certainty of evidence and strength of recommendation. The video explains the process of grading evidence, including starting grades based on study design, possible downgrades (study limitations, inconsistency, indirectness, imprecision, publication bias), and possible upgrades (magnitude of effect, dose-response association, controlling for confounders). The overall certainty of evidence is determined by considering the lowest grade among critical outcomes. The video also introduces GradePro, a software that facilitates the creation of grade tables, and provides examples of grade symbols and tables used to summarize evidence. Additionally, the video suggests reading two articles related to a specific research question and evaluating their design, reliability, directness, consistency, and precision.<br /><br />No credits were mentioned in the video.

Keywords

GRADE system

evidence-based medicine

certainty of evidence

strength of recommendation

grading evidence

GradePro software

grade symbols

grade tables