ASAP Live - Diabetes 2-Slides

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Islet cell and pancreas transplantation can be considered for patients with Type 1 Diabetes who have failed insulin-based management and suffer from frequent acute and severe metabolic complications. In the case of this 43-year-old woman with poorly controlled Type 1 Diabetes, she has experienced severe hypoglycemia and diabetic ketoacidosis, resulting in a high Clarke score for impaired hypoglycemia awareness. She also has a high disease burden and struggles with daily diabetes management. Pancreas transplantation alone (PTA) or islet transplantation alone (ITA) are potential options for her. <br /><br />The International Pancreas Transplant Registry shows that PTA has a patient survival rate of over 95% at one year and over 90% at five years, with graft survival rates up to 94%. PTA can relieve her burden of daily diabetes management and prevent future diabetes complications. <br /><br />Islet transplantation is a rapidly evolving technology that requires further research, but recent advancements have improved success rates. ITA has resulted in insulin independence with improved glycemic control and reduced hypoglycemic events. However, it is currently only performed under investigative protocols at a few centers. <br /><br />Considering the patient's high Clarke score, disease burden, and failure of current therapies, she would be an ideal candidate for ITA or PTA. Advanced diabetes technologies would only increase her anxiety and diabetes burnout. <br /><br />It is important for her to consult with her healthcare team and consider the available transplantation options to determine the best course of action for her specific case.

Keywords

islet cell transplantation

pancreas transplantation

Type 1 Diabetes

severe hypoglycemia

diabetic ketoacidosis

Clarke score

daily diabetes management

graft survival rate

glycemic control

transplantation options