ASAP Live 2021 extra-Bone & Parathyroid Video

Video Transcription

Video Summary

Summary: The video discusses six cases related to bone and parathyroid disorders. The first case involves a woman with hypercalcemia due to loss of function mutation in the CYP24A1 gene, leading to impaired inactivation of vitamin D. The correct management option is Ketoconazole. The second case involves a woman with osteoporosis and a family history of hip fractures who would benefit from intravenous Zoledronic acid. The third case involves a man with XLH, characterized by low phosphorus, high FGF23, and a family history of kidney stones. The correct next step is a 24-hour urine calcium and creatinine measurement. The fourth case involves a transplant patient on glucocorticoid therapy with osteopenia. The correct recommendation is Alendronate combined with lifestyle modifications. The fifth case involves a woman with refractory hypocalcemia, which is likely due to hypomagnesemia. The correct next step is to measure magnesium levels. The final case involves a patient with hypocalcemia and recent gastrointestinal illness, where the correct next step is also to measure magnesium levels.

Keywords

bone disorders

parathyroid disorders

hypercalcemia

CYP24A1 gene

Ketoconazole

osteoporosis

Zoledronic acid

XLH

low phosphorus