AACE Rare Endocrine Disease Series On Demand: Fatigue, Abnormal Body Composition and Bone Loss: Is Adult GHD to Be Blamed?-AACE Rare Endocrine Disease Series On Demand: Fatigue, Abnormal Body Composition and Bone Loss: Is Adult GHD to Be Blamed?

AACE Rare Endocrine Disease Series On Demand: Fatigue, Abnormal Body Composition and Bone Loss: Is Adult GHD to Be Blamed?

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Video Summary

The ACE Rare Diseases webinar, led by Dr. Kevin Yuen and Chris Yadinak, focused on Adult Growth Hormone Deficiency (AGHD), specifically addressing fatigue, abnormal body composition, and bone loss as potential symptoms. The discussion covered the diagnosis, guidelines, and treatment of AGHD, emphasizing the critical role growth hormone plays beyond childhood growth—affecting metabolism, body composition, and psychological well-being.<br /><br />The webinar stressed common causes of AGHD, such as pituitary surgeries, radiation, and brain injuries, urging careful screening only in at-risk populations. They outlined diagnostic strategies, highlighting the importance of IGF-1 levels and growth hormone stimulation tests, while noting the limitations and challenges of these methods, including inconsistent results and cumbersome testing procedures.<br /><br />In treatment discussions, the session highlighted advancements like long-acting growth hormone preparations, which improve patient adherence due to less frequent dosing. The webinar addressed the controversies and safety concerns surrounding growth hormone therapy, like its potential misuse for anti-aging, and the lack of substantial data on long-term effects like fertility and cancer risks in older patients.<br /><br />The session concluded with an interactive Q&A, discussing aspects of hormone replacement therapy and the intricacies of managing AGHD, including transitioning from pediatric to adult care, the potential need for dose adjustments in concurrent therapies, and considerations for special populations like post-acromegaly surgical patients.

Keywords

Adult Growth Hormone Deficiency

AGHD

fatigue

abnormal body composition

bone loss

growth hormone therapy

IGF-1 levels

diagnostic strategies

long-acting growth hormone

hormone replacement therapy

pituitary surgeries