AACE MENA 2025-Roundtable Case Based Discussion

Roundtable Case Based Discussion - Tamer Elsherbiny

Video Transcription

Video Summary

This case report describes a 50-year-old female nurse with autoimmune thyroid disease who initially presented with hypothyroidism and positive thyroid antibodies, treated with levothyroxine. Over five years, her condition shifted to Graves' disease with suppressed TSH and elevated thyroid hormones, treated with carbimazole. After four years, hypothyroidism recurred following carbimazole cessation. The report discusses rare autoimmune thyroid transitions between hypothyroidism and hyperthyroidism, involving TSH receptor antibodies of stimulating and blocking types. Mechanisms include changes in antibody profiles and immune modulation by treatment. A case series from Egypt and possible triggers like smoking cessation were also reviewed.

Keywords

autoimmune thyroid disease

hypothyroidism

Graves' disease

TSH receptor antibodies

carbimazole treatment