#AACE2021: Top 20-Vitamin D in the Era of Precision Medicine

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Video Summary

Dr. Michael Levine, Chief Emeritus of Endocrinology and Diabetes at the Children's Hospital of Philadelphia, gave a lecture on the topic of vitamin D in the era of precision medicine. He discussed the effects of vitamin D deficiency, the factors that influence vitamin D homeostasis, and the role of genetics in vitamin D metabolism. Dr. Levine highlighted the importance of precision medicine in optimizing vitamin D therapy, as individual variability in genes, environment, and lifestyle can affect vitamin D status. He emphasized that vitamin D deficiency is common in the general population, especially among certain demographic groups such as young adults and non-Hispanic blacks. The primary clinical manifestations of vitamin D deficiency are rickets and osteomalacia, which reflect the impact of vitamin D on bone and mineral metabolism. Dr. Levine also mentioned the potential non-bone effects of vitamin D deficiency, such as associations with diabetes, heart disease, and infections, but noted that the evidence for treating these conditions with vitamin D supplementation is inconclusive. He discussed the various risk factors for vitamin D deficiency, including limited sunlight exposure, poor dietary intake or absorption, and genetic factors. Dr. Levine explained that different individuals may require personalized treatment plans for vitamin D deficiency based on their specific risk factors and genetic variations. He mentioned the importance of regular monitoring of serum 25-hydroxyvitamin D levels during treatment and highlighted the need to consider calcium supplementation for patients with underlying metabolic bone disease or reduced serum calcium levels. Overall, Dr. Levine's lecture emphasized the significance of precision medicine in optimizing vitamin D therapy and improving patient outcomes.

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Michael Levine, MD | Felice Caldarella, MD, FACP, CDCES, FACE

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Keywords

Dr. Michael Levine

Chief Emeritus

Endocrinology

Diabetes

Children's Hospital of Philadelphia

vitamin D

precision medicine

vitamin D deficiency

genetics

vitamin D metabolism