#AACE2021: Top 20-Triglycerides - Medications and Trials

Video Transcription

Video Summary

In this video, Dr. Betu Hatipoglu discusses triglycerides, medications, and clinical trials. She explains that triglycerides in the body are derived from dietary fat and internally produced free fatty acids, and that high triglyceride levels can increase the risk of pancreatitis. She also mentions that secondary causes of hypertriglyceridemia, such as uncontrolled diabetes, pregnancy, and certain medications, should be considered and managed in addition to the disease-specific treatment. Dr. Hatipoglu emphasizes the importance of lifestyle factors, such as weight loss, carbohydrate restriction, and exercise, in managing mild to moderate elevation of triglycerides. She reviews the medications commonly used for treating hypertriglyceridemia, including statins, fibrates, and omega-3 fatty acids. Dr. Hatipoglu discusses the results of clinical trials, such as the REDUCE-IT trial, which showed that high-dose EPA (a type of omega-3 fatty acid) significantly reduced cardiovascular events in patients with elevated triglycerides. She also mentions other emerging treatment options, such as gene therapy and novel drugs that target proteins involved in triglyceride metabolism. Overall, the video provides an overview of the causes, management, and treatment options for hypertriglyceridemia, with a focus on the latest research and clinical trials.

Asset Subtitle

Betul Hatipoglu, MD | Jennifer Gilligan, MD, PhD

Keywords

triglycerides

medications

clinical trials

pancreatitis

hypertriglyceridemia

lifestyle factors

weight loss

statins

omega-3 fatty acids