#AACE2021: Top 20-Evaluation and Management of Suspicious Adrenal Masses

Video Transcription

Video Summary

The video is a symposium on the evaluation, management, and treatment of suspicious adrenal masses and advanced adrenocortical carcinoma (ACC). It is divided into three parts, with presentations by Dr. Anand Vaidya, Dr. Mohammad Habra, and Dr. Abbas Habra.<br /><br />Dr. Vaidya's presentation focuses on the evaluation and management of incidentally discovered adrenal masses. He discusses the prevalence, malignancy, and functionality of these masses, as well as the diagnostic approach. Dr. Vaidya provides an algorithm for management based on clinical, biochemical, and radiographic characteristics.<br /><br />Dr. Mohammad Habra's presentation focuses on the management of advanced ACC. He discusses the prognosis, poor prognostic factors, and hormonal overproduction in ACC patients. Dr. Habra outlines the different treatment modalities, including hormonal management, surgery, chemotherapy, targeted therapy, and palliative therapy.<br /><br />Dr. Abbas Habra's presentation discusses the use of monoclonal antibodies and linsitinib in ACC treatment. They mention their limited responses and highlight the potential use of capozantinib, a drug targeting HGF and CMAT receptors. Data from a retrospective series show partial responses and stable disease in some patients. The role of immunotherapy, particularly pembrolizumab, is also discussed, with data from phase II studies. The combination of tyrosine kinase inhibitors and pembrolizumab is mentioned as a potential option.<br /><br />The speakers emphasize the need for a multidisciplinary approach in managing advanced ACC and highlight ongoing research for improved treatment options. The video credits the American Association of Clinical Endocrinology.

Asset Subtitle

Anand Vaidya, MD, MMSc | Mouhammed Amir Habra, MD | Irina Bancos, MD

Keywords

symposium

adrenal masses

adrenocortical carcinoma

evaluation

management

incidentally discovered

diagnostic approach

treatment modalities

hormonal management

chemotherapy

immunotherapy

multidisciplinary approach